Luminal cells with an identity crisis

Oncolytic Viruses: Therapeutics With an Identity Crisis

Oncolytic viruses (OV) are replicating viral therapeutics for the treatment of cancer and have been in laboratory development for about twenty years. Recently, the FDA approved Imlygic, a herpes virus based therapeutic for the treatment of melanoma and thus OVs have entered a new era where they are a weapon in the armament of the oncologist. OVs are unique therapeutics with multiple mechanisms ...

Identity crisis?

This article responds to arguments made in a recent paper by Bucholtz and Hall (Bucholtz, M., Hall, K., 2004. Theorizing identity in language and sexuality research. Language in Society 33, 469–515), in which two contrasting approaches to language and sexuality, dubbed ‘‘identity-based’’ and ‘‘desire-centered’’, are identified, and the latter is critiqued. As well as seeking to correct some ina...

Are we having an identity crisis?

An Identity Crisis in the Life Sciences

Grid is an e-Science project assisting life scientists to build workflows that gather and co-ordinate data from distributed, autonomous, replicated and heterogeneous resources. The provenance logs of workflow executions are recorded as RDF graphs. The log of one workflow run is used to trace the history of its execution process; however, by aggregating provenance logs of workflow reruns, or run...

Adult neurogenesis in mammals: an identity crisis.

The study of neurogenesis in the adult brain is among the most exciting and fastest moving areas of neuroscience today. In contrast to the high rate of neurogenesis in some vertebrates (Nottebohm, 2002), unambiguous evidence for new neurons in normal adult mammals ranging from rodents to primates has been confined to the dentate gyrus and olfactory bulb (Lois and AlvarezBuylla, 1964; Kaplan and...